3 years local recurrence and distant metastasis rates after hypofractionated and conventional radiotherapy in post mastectomy breast cancer patients

Lalit Mohan Patel; Neha Kurmi Patel

Volume : VIII, Issue : VII, July - 2019

3 years local recurrence and distant metastasis rates after hypofractionated and conventional radiotherapy in post mastectomy breast cancer patients

Lalit Mohan Patel, Neha Kurmi Patel

Abstract :

Introduction: Carcinoma of the east is the commonest cancer in urban Indian women. Radiotherapy is commonly given after mastectomy in east cancer patients and it targets post surgery tumor site. Radiotherapy has shown to improve local control and overall survival. Objectives: To compare local recurrence and distant metastasis rates after hypofractionated and conventional radiotherapy in post mastectomy east cancer patients after 3 years follow up. Material and Methods: Study was prospective and patients were divided into 2 groups. Group A patients were given hypofractionated radiotherapy -40 Gy/17 fractions/3.2 weeks@2.35 Gy/fraction while Group B patients were given conventional radiotherapy -50 Gy/25 fractions/5 weeks @2 Gy/fraction. They were followed for 3 years after giving radiotherapy. Results: Out of 40 patients of group A, 5 patients showed local recurrence(12.5%) while 5 patients showed distant metastasis(12.5%). On the other hand, out of 40 patients of group B, 6 patients showed local recurrence(15%) while 3 patients showed distant metastasis(7.5%). Conclusion: Overall 77.5% patients of group B showed no evidence of disease while 75% patients of group A found to be disease free. Thus, we concluded that both the fractionation radiotherapy schedules showed no significant difference statistically (p>0.05) in local recurrence and distant metastasis rates. Thus, both radiotherapy regimens can be used in treatment of east cancer patients after mastectomy.