A CLINICAL COMPARATIVE STUDY OF MYCOPHENOLATE MOFETIL VERSUS PREDNISOLONE FOR HIGH RISK PENETRATING KERATOPLASTY

Dr Naveen K; Dr Safia Ahmed

Volume : IV, Issue : I, January - 2015

A CLINICAL COMPARATIVE STUDY OF MYCOPHENOLATE MOFETIL VERSUS PREDNISOLONE FOR HIGH RISK PENETRATING KERATOPLASTY

Dr Naveen K, Dr Safia Ahmed

Abstract :

Purpose : To study the efficacy and safety of Mycophenolate Mofetil (MMF) in preventing graft rejection in high risk Penetrating keratoplasty(PK) . Methods : Data records of last five years of high risk corneal transplants at two tertiary care hospitals were reviewed. Cases were divided into those who received mycophenolate mofetil for one year versus those who were given systemic steroids. The main outcome measures were immune reaction free & clear graft survival . Results : A total of 400 patients ,210 in steroid group and 190 in MMF group, underwent PK in the affected eye including combined Cataract extraction in 146 eyes with mean follow up of 2 years 3 months. Significantly less graft rejection was seen in MMF versus steroid group ( 73 versus 19). Conclusions :Systemic immunosuppression with MMF reduces rejection rate with better corneal graft survival as compared to systemic steroids in high risk PK.