A CLINICAL COMPARATIVE STUDY OF TWO INTUBATING DOSES OF CIS-ATRACURIUM DURING GENERAL ANAESTHESIA FOR RENAL TRANSPLANT SURGERIES.

Dr. Akruti Modi; Dr. Brijal N. Patel

Volume : VII, Issue : XI, November - 2018

A CLINICAL COMPARATIVE STUDY OF TWO INTUBATING DOSES OF CIS-ATRACURIUM DURING GENERAL ANAESTHESIA FOR RENAL TRANSPLANT SURGERIES.

Dr. Akruti Modi, Dr. Brijal N. Patel

Abstract :

Introduction: Cisatracurium unlike atracurium is devoid of histamine-induced cardiovascular effects and this alone would be the greatest advantage in replacing atracurium for the facilitation of tracheal intubation. On the other hand, 2xED₉₅dose of cisatracurium (100micro/kg) do not yield satisfactory intubating conditions such as those seen with equipotent doses atracurium and therefore there commended intubating dose of cisatracurium is 3xED₉₅ . To understand better, we evaluated intubating condition with diferent doses of cisatracurium in renal transplant surgery.

Aims & objectives: To evaluate and compare the intubating condition, duration of action, hemodynamic effects for different doses of cisatracurium.

Material & methods: After informed patient�s consent 60 patients in age group of 20-50 years were selected and included in the study. Patients were divided in two groups of 30 each, GROUP-A received intravenously 2×ED₉₅ (0.1mg/kg) dose of cisatracurium and GROUP-B received intravenously 3×ED₉₅(0.15mg/kg) during induction.

Results :Better intubating condition,hemodynamic stability and longer duration of action was found with 0.15mg/kgdose of Cisatracurium than 0.1mg/kg Cisatracurium in a induction