A STUDY OF EFFECTS OF PREMDICATION WITH ORAL CLONIDINE ON HAEMODYNAEMIC CHANGES IN PATIENTS UNDERGOING LAPAROSCOPIC SURGERIES

Dr. Shivali Pandey; Dr Shailendra Dawar

Volume : VII, Issue : II, February - 2018

A STUDY OF EFFECTS OF PREMDICATION WITH ORAL CLONIDINE ON HAEMODYNAEMIC CHANGES IN PATIENTS UNDERGOING LAPAROSCOPIC SURGERIES

Dr. Shivali Pandey, Dr Shailendra Dawar

Abstract :

Objectives To assess the efficacy of oral clonidine 2-2.5mcg/kg as a premedication and its effect on haemodynamic changes associated with creation of pneumoperitoneum in laparoscopic surgery.Finally to evaluate and compare the side effects and complications in control and study group.

Methodology The patients were randomly allocated to two groups of 30 each study and control group.The study group received oral clonidine 2-2.5mcg with a sip of water 90 min prior to surgery.The control group received ora vit. c tablets as placebo with a sip of water 90 min prior to surgery. Systematic arterial pressure including the systolic diastolic and mean arterial pressure heart rate SpO₂ and EtCO₂were timely recorded.

Results The results of the study indicate that premedication with oral clonidine (2-2.5mcg) in laparoscopic surgeries effectively counteracts the haemodnamic changes due to creation of pneumoperitoneum.The observations were discussed in terms of pulse rate , blood pressure SpO₂ ETCO2, post operative pain defined by VAS sedation score and side effects and it wasseen that Clonidine causes clinically significant reduction in pulse rate and blood pressure intraoperatively. Clonidine treated patients were sedated and comfortable postoperatively .The incidence of side effects was minimum in clonidine treated patients.

Conclusion.Premedication with oral clonidine (2-2.5mcg/kg) proved better than placebo in counteracting the haemodynaemic changes in laparoscpic surgeries.Clonidine causes clinically significant reduction in pulse rate and blood pressure intraoperatively. Clonidine treated patients were sedated and comfortable postoperatively .The incidence of side effects was minimum in clonidine treated patients.