Volume : VI, Issue : III, March - 2017

A STUDY OF EFFICACY OF PACLITAXEL ALONG WITH DI ALLYL SULFIDE ON LACTATE DEHYDROGENASE ENZYME ACTIVITY CHANGES IN 7,12 DI METHYL BENZ(A) ANTHRACENE INDUCED SKIN CANCER WISTAR RATS

Dr. M. Chandrasekar, Dr. N. Muninathan

Abstract :

 Aim: The purpose of this study is to investigate the changes in the levels of lactate dehydogenase enzyme (LDH) activity  and efficacy of  combination of paclitaxel along with Di allyl sulfide against skin cancer in experimental animals.  skin cancer is the commonest cancer in all developed countries (except Japan) as well as in North Africa, South America, and southeastern and western Asia. While the incidence of skin cancer appears to be increasing, mortality rates are now declining in at least some western countries. The most common warning sign of skin cancer is a change in the appearance of the skin, such as a new growth or a sore that will not heal. Skin cancer is caused by chemical carcinogens and  Papilloma virus infection. Methods: Skin cancer was induced in rats by 7, 12 Di methyl benz(a) anthracene (DMBA) at the dosage of 5 g   dissolved in 100l acetone and administered into experimental animals  for 28 weeks. In this study, we demonstrated that combination of paclitaxel and Di allyl sulfide  revert the changes in the rats from lethal dose of DMBA  within 30 days. Results: All the isoenzymes LDH1 – LDH5 were observed in cancer be animals. Expression of these isoenzymes were found be reduced in paclitaxel  and Di allyl sulfide treated animals. Conclusions: The treatment with combination of paclitaxel and Di allyl sulfide effectively reduced LDH enzyme activity levels. So, from the obtained results it is concluded that paclitaxel and Di allyl sulfide is capable of restoring the Skin architecture.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Dr. M.Chandrasekar, Dr.N. Muninathan, A STUDY OF EFFICACY OF PACLITAXEL ALONG WITH DI ALLYL SULFIDE ON LACTATE DEHYDROGENASE ENZYME ACTIVITY CHANGES IN 7,12 DI METHYL BENZ(A) ANTHRACENE INDUCED SKIN CANCER WISTAR RATS, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-6, Issue-3, March‾2017


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