A STUDY ON SITAGLIPTIN AND REPAGLINIDE IN THE MANAGEMENT OF UNCOMPLICATED TYPE 2 DIABETES MELLITUS

Pravin kumar singh; Ritesh kumar Sinha; Jaleshwar Prasad

Volume : IX, Issue : IV, April - 2020

A STUDY ON SITAGLIPTIN AND REPAGLINIDE IN THE MANAGEMENT OF UNCOMPLICATED TYPE 2 DIABETES MELLITUS

Pravin Kumar Singh, Ritesh Kumar Sinha, Jaleshwar Prasad

Abstract :

Introduction :GLP-1and GIP stimulates glucose dependent insulin secretion by pancreatic β-cells and GLP-1 also suppressed glucagon release by pancreatic alpha cell in glucose dependent fashion. Through these mechanism, DPP-4 inhibitors improve control of postprandial glucose excursions and lower fasting plasma glucose (FPG) in patient with type-2 diabetes . Aims and Objectives1.To observe the effect of sitagliptin and repaglinide on plasma glucose level fasting and post prandial.2.To observe the effect of sitagliptin and repaglinide on HBA1c.3.To observe the effect of sitagliptin and repaglinide on weight of patient. Materials and Method The current study had been designed, single blind, study with two parallel treatment groups. The duration of the study was 24 weeks for each subject from the commencement of study medications. Group A – Sitagliptin 100mg OD: Group B – Repaglinide Discussion mean glycosylated hemoglobine level in Group A decreased from 9.14 % at 0 week to 6.97 % at 24 week and in Group B decrease from 8.78 % at 0 week to 7.48 % at 24 week