Volume : IX, Issue : V, May - 2020

A STUDY TO ASSESS CORRELATION OF SEVERITY OF DIABETIC RETINOPATHY WITH SERUM HOMOCYSTEINE LEVELS IN TYPE2 DM

Dr Samiksha Agrawal, Dr Anjul Garg, Dr U S Tiwari

Abstract :

Objective: To evaluate the prevalence of high Plasma Homocysteine levels in diabetic patients and its correlation with nonproliferative diabetic retinopathy (NPDR) and with proliferative diabetic retinopathy (PDR) . Besides, this study also aims at determining association between glycemic control, serum creatinine levels and with serum homocysteine levels. Research design and methods: this hospital-based, case control study was conducted on 50 patients aging between 40 and 70 years attending the outpatient department of ophthalmology of J.A.Hospital, Gwalior from January 2018 to June 2019. Method used for Homocysteine estimation was Auto pure homocysteine assay. Results : There was statistically significant difference observed between the three groups viz. PDR, NPDR and NO DR, with respect to glycemic control (7.55±1.55, 7.60±2.88 and 5.97±.93 respectively, p = 0.04) and duration of diabetes (80±31.7, 68±44.3 and 39±54.8 respectively , p = 0.025) . Although the mean (+ SD) levels of serum homocysteine was higher among the PDR, NPDR as compared to NO DR, the difference was not statistically significant (15.56 ± 4.82μmol/L in PDR, 14.02±2.83 μmol/L in NPDR and 12.99±4.7μmol/L in NO DR ; p = 0.47). There was no statistically significant difference in the prevalence of hyperhomocysteinemia between cases and controls, when hyperhomocysteinemia was defined as serum homocysteine level > 15.00 μmol/L. Conclusion: Since diabetes is a microvascular occlusive disease, adjuvant risk factors contributing to a hypercoagulability state, such as increased levels of plasma homocysteine, may accelerate or aggravate the development or progression of diabetic retinopathy.

Keywords :

Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

A STUDY TO ASSESS CORRELATION OF SEVERITY OF DIABETIC RETINOPATHY WITH SERUM HOMOCYSTEINE LEVELS IN TYPE2 DM , Dr Samiksha Agrawal, Dr Anjul Garg, Dr U S Tiwari GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-9 | Issue-5 | May-2020


Number of Downloads : 134


References :