Volume : VIII, Issue : II, February - 2019

A STUDY TO FIND THE EFFICACY OF PREGABALIN IN IMMEDIATE POST-OPERATIVE PAIN CONTROL

Dr Giles George

Abstract :

Pregabalin is a structural analogue of the inhibitory neurotransmitter γ-amino butyric acid but it is not functionally related to it. Like its predecessor gabapentin it binds to the α-2-δ subunit of voltage-gated calcium channels reducing the release of several excitatory neurotransmitters and blocking the development of hyprealgesia and central sensitization. Pregabalin has anticonvulsant antihyperalgesic and anxiolytic properties similar to gabapentin, but it has a more favorable pharmacokinetic profile including dose-independent absorption. It is also several times more potent than gabapentin while producing fewer adverse effects. Recently it has been introduced as an adjunct in the multimodal management of postoperative analgesia .Recently the role as oral pre-emptive analgesic of pregabalin for postoperative pain relief has been reviewed. This study puts in a effort to find the efficacy of this drug in controlling the post-operative pain.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

A STUDY TO FIND THE EFFICACY OF PREGABALIN IN IMMEDIATE POST-OPERATIVE PAIN CONTROL, Dr Giles George GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-8 | Issue-2 | February-2019

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