Volume : V, Issue : II, February - 2016

Allergic Rhino-sinusitis and Bronchial Asthma Co-existence: Is it A Functional or Anatomical Correlation?

Amjad F. M, Aamir A. M, Kamaleldin B. , Yasser S. A

Abstract :

 Background: Few studies were conducted to explore the correlation between onchial asthma and allergic rhinosinusitis. Objectives: To clarify the nature of co-morbidity between onchial asthma and allergic rhino-sinusitis. Materials and methods: A cross sectional hospital-based study was conducted during the year 2014. A total of 83 subjects were selected and classified into four groups: 23 normal subjects as control in group (1); 20 asthmatic patients (group 2); 20 patients with rhino-sinusitis (group 3); and 20 patients with co-morbid asthma and rhino-sinusitis (group 4). CT scan (coronal sections) of paranasal air sinuses and pulmonary function tests were done for all participants under the study. Results: Anatomical abnormalities were identified in the maxillary, frontal, and ethmoid sinuses in the form of mucosal thickening, bony wall erosion, complete opacification and polyps in all groups under the study. However, compared to the control group (normal subjects), the mucosal thickening and polyps were more evident in the maxillary sinus in group 2 (asthma only, p= 0.013), group 3 (rhino-sinusitis only, p=0.001) and group 4 (co-morbid asthma plus rhino-sinusitis, p= 0.013). Pulmonary function tests were found to be significantly impaired in asthma only group, p = 0.026 for FEV1) and co-morbid group (p= 0.046 for FEV1). Compared to control group, the mean FEV1 (L) was significantly reduced in patients with maxillary sinus abnormalities among asthmatic and co-existence groups (p < 0.001). Conclusion: Maxillary sinus abnormalities could partially explain asthma and rhino-sinusitis co-existence as it predisposes to allergic reaction and generation of systemic inflammatory mediators that lead to functional impairment in both upper and lower respiratory tracts

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Amjad F.M, Aamir A.M, Kamaleldin B., Yasser S.A Allergic Rhino-sinusitis and Bronchial Asthma Co-existence: Is it A Functional or Anatomical Correlation? Global Journal For Research Analysis, Vol: 5, Issue: 2 February 2016


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