Evaluating Musculoskeletal Complications Among Individuals With Diabetes Mellitus

Dr. Simran Maheshwari; Dr. Subhan Quraishi; Dr. Babita Ghodke

Volume : II, Issue : III, March - 2013

Evaluating Musculoskeletal Complications Among Individuals With Diabetes Mellitus

Dr. Simran Maheshwari, Dr. Subhan Quraishi, Dr. Babita Ghodke

Abstract :

Malaria remains one of the most important diseases of man with over half of the world�s population at a risk of infection and 1–2 million deaths annually. The emergence and rapid spread of of Chloroquine resistant strains of Plasmodium falciparum has dramatically reduced the Chemotherapeutic options. It is important to recognize that antiparasitic drug discovery differs in many ways from drug discovery for the chronic conditions that have become a primary focus of the pharmaceutical industry today. A short review of the antimalarial drugs currently used in human clinics reported. Amodiaquine (AQ) (2) is a 4–Aminoquinoline antimalarial that can cause adverse effects including agranulocytosis and liver damage. This study describes the synthesis of new 4–Aminoquinoline derivatives and evaluation of their activity against Chloroquine–sensitive strain of Plasmodium falciparum invitro and Chloroquine–resistant N–67 strain of Plasmodium yoelli invivo. It is clear that Chloroquine resistant parasites accumulate fewer drugs than sensitive strains. It has been synthesized a new series of Chloroquine analogues where the diethylamino isopentyl function of the side chain has been replaced by shorter side chains, containing metabolically more resilient terminal secondary and tertiary alkyl amino group.