Assessing the effects of Sodium Valproate on Liver Function test in patients of Bipolar disorder

Dr.Dharmesh N. Gamit; Dr.Dharmesh K. Patel; Dr. Avanish Mishra; Dr.Hariom Sharma; Dr.Kalpana Gamit

Volume : V, Issue : VIII, August - 2016

Assessing the effects of Sodium Valproate on Liver Function test in patients of Bipolar disorder

Dr. Dharmesh N. Gamit, Dr. Dharmesh K. Patel, Dr. Avanish Mishra, Dr. Hariom Sharma, Dr. Kalpana Gamit

Abstract :

The study comprised effects of sodium valproate on liver in patients of bipolar disorder. In the present study 75 known patients of Bipolar disorder were enrolled and subjected to various biochemical investigations initially and after 3 months of treatment with Sodium Valproate. Venous blood samples (5ml) were collected from all the patients and analyzed for Bilirubin, Alanine aminotransferase ,Aspartate aminotransferase , Alkaline phosphatase and pseudocholinesterase . The levels of ALT and AST (p<0.001) were significantly increased and Pseudocholinesterase levels were significantly decreased , but there were no stastical significant changes in the levels of Alkaline Phosphtase and Bilirubin. In the Present study Alterations in the levels of Alanine aminotransferase and Aspartate aminotransferase show positive indication that treatment with Sodium Valproate affect the liver function, which suggest periodic monitoring of liver function test in the patients receiving long term sodium Valproate therapy