Assessment of Oxidative Stress Markers and Lipoprotein(a) in Patients with Stroke in a Tertiary Care Hospital

Syed Tousif Ahmad Rizvi; Mohd Aslam; M Mobarak Hossain; M Shoaib Zaheer

Volume : VII, Issue : IX, September - 2018

Assessment of Oxidative Stress Markers and Lipoprotein(a) in Patients with Stroke in a Tertiary Care Hospital

Syed Tousif Ahmad Rizvi, Mohd Aslam, M Mobarak Hossain, M Shoaib Zaheer

Abstract :

Objective:To study the status of oxidative stress markers such as Superoxide Dismutase(SOD), Glutathione Peroxidase(GPx), product of lipid peroxidation Malondialdehyde(MDA) and serum Lipoprotein(a) concentrations in cases i.e. stroke subjects.Materials and Methods: A total of 28 subjects, fourteen (14) cases and fourteen (14) controls were selected as per convenience keeping in mind the logistics and time constraints.Patient admitted to medicine wards with established diagnosis of stroke were taken as cases. The diagnosis was established on the basis of history, clinical examination and imaging studies. While age and sex matched controls were randomly selected from Medicine OPD. Unpaired T- test was used for statistical significance. A value less than 0.05 was considered as significant.Results: Glutathione peroxidase(GPx) levels were lower in cases than in controls (P <0.05).Superoxide dismutase(SOD) levels were very low in cases than in controls(P <0.001).Malondialdehyde(MDA) levels were higher in cases than in controls but relationship was not found to be significant(p>0.05). Lipoprotein (a) levels were very high in cases than in controls(P <0.001).Conclusion:The present study reveals reduced GPx and SOD while MDA and Lipoprotein(a) levels were high in stroke subjects in first 24 hours.This indicates prominent role ofreduced GPx and SOD in increase of oxidative stress during early ischaemic period.Further it was also found that increased Lipoprotein(a) in early ischaemic period is associated with higher risk of stroke. Measurement of these biomarkers can quantify the risk of stroke.