Volume : VII, Issue : XII, December - 2018

ASSOCIATION BETWEEN SERUM VITAMIN D LEVEL AND CLINICAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS

Zuhrial Zubir, Meivina Ramadhani Pane, Darmadi

Abstract :

 

Introduction. The role of vitamin D in immunomodulatory is established suggesting its association in affecting autoimmune diseases such as systemic lupus erythematosus (SLE). In spite of its importance, particularly in South Asia, vitamin D inadequacy is common. International studies have shown vitamin D deficiency has been frequently reported in SLE populations and is associated to multiple manifestations of SLE, though mixed results have been reported in terms of its relation to certain clinical manifestations of SLE.

Aim. In the current study, we aimed to evaluate the association between serum vitamin D level with specific clinical manifestations clasically found in SLE patients.

Methods. This was retrospective study from medical records of patients with SLE who came to Adam Malik General Hospital, Medan, Indonesia during the year of 2015-2017. Data on clinical manifestations, serum vitamin D level, ANA and anti-dsDNA level were assesed. Vitamin D status was assesed by measuring serum 25(OH)D concentration using standard cut-off value.

Results. A total number of 50 SLE cases were included in this study. Among SLE patients, 48% was vitamin D insufficient whilst 32% was vitamin D deficient. Only 20% of subjects showed normal level of vitamin D. This current study found significant association between serum vitamin D concentration with photosensitivity (median 14.9, p = 0.004), renal impairment (median 15.25, p = 0.021), and hematology disorder (median 16.2, p = 0.009). This study did not found significant correlation between vitamin D level with both ANA and anti-dsDNA.

Conclusion. This study showed a high prevalence of vitamin D inadequacy in SLE patients residing in our region. We reported significant associations between vitamin D level with photosensitivity, renal impairments and hematology disorders in SLE patients. In terms of SLE-specific antibody titer, we did not find significant correlation between vitamin D with anti-dsDNA.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

ASSOCIATION BETWEEN SERUM VITAMIN D LEVEL AND CLINICAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS , Zuhrial Zubir, Meivina Ramadhani Pane, Darmadi , GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-7| Issue-12 | December-2018


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