Association of CXCR1 expression with Histological grade and Clinical stage of Oral Squamous Cell Carcinoma.

DR Basavaraj Kallapur; DR Wafa  Awedat; DR.Omneya Mahomoud

Volume : VI, Issue : VII, July - 2017

Association of CXCR1 expression with Histological grade and Clinical stage of Oral Squamous Cell Carcinoma.

Dr Basavaraj Kallapur, Dr Wafa Awedat, Dr. Omneya Mahomoud

Abstract :

Background:. Interleukin-8 (IL-8) is a pro-inflammatory cytokine which exerts its effects via binding to CXCR1 and is known to promote angiogenesis. CXCR1 represent potential prognostic biomarkers and therapeutic target.

Aim of the study: To evaluate the expression of CXCR1 in OSCC and control tissue as well as correlate the expression of the CXCR1to the clinicopathologic parameters of OSCC .

Material and Methods: Immunohistochemical analysis of 22 cases OSCC and 7 control cases sections stained by anti-CXCR1antibody. Immunohistochemical staining will be performed using a Labeled Strept-Avidin Biotin complex method (LSAB).

Results:Expression was recognized in all cases of OSCC and normal control cases and the pattern of expressed in both the cytoplasm and nucleus of the malignant epithelial cells (total cell reactivity), as well as high expression was noticed in low histological grade and clinical stage malignancy, whereas decrease of expression was detected in high grade and stage malignancy.

Conclusions: the results show an association between CXCR1and the clinicopathologic parameters, and considered as prognostic marker in OSCC.