ASSOCIATION OF NEUREGULIN 1 LEVELS, MATERNAL AND NEONATAL RISK FACTORS WITH BLOOD GLUCOSE LEVELS IN PRETERM INFANTS

Bugis Mardina Lubis

Volume : VIII, Issue : I, January - 2019

ASSOCIATION OF NEUREGULIN 1 LEVELS, MATERNAL AND NEONATAL RISK FACTORS WITH BLOOD GLUCOSE LEVELS IN PRETERM INFANTS

Bugis Mardina Lubis

Abstract :

Background : Prematurity remains as the most common cause of morbidity and mortality in neonatal period. Maternal and neonatal risk factors associated with prematurity had been identified before. Neuregulin (NRG) 1 plays important role in the development of lungs, heart and ain of the infants. Preterm infants are vulnerable population to develop problems due to disturbance in NRG 1 gene expression, which associated to various condition. The association between NRG 1 levels and blood glucose levels in preterm infants remains unclear. Objective : To determine the association of NRG 1 levels, maternal and neonatal risk factors with blood glucose levels in preterm infants. Design and Methodology : A cross-sectional study on 50 consecutive preterm infants on hospitals in Medan, Indonesia from June to August 2018. Maternal and neonatal risk factors were recorded. Blood glucose levels were obtained from venous blood sample and were checked serially from the time of delivery within the first hour of life until discharged from hospital or 72 hours of age. Univariate and bivariate (Chi square and Fisher exact test) analysis were performed with 95% CI and P value <0.05 were considered statistically significant. Result : Out of 50 preterm infants, 13 infants had hypoglycemia (26%). There was no association between maternal risk factors with hypoglycemia. Regarding neonatal risk factors, birth weight of ≤2500 gr and gestational age of 32–<35 weeks were associated with hypoglycemia (P=0.010 and P=0.021, respectively). NRG 1 levels had median of 180,6 pg/mL. Preterm infants who developed hypoglycemia had lower NRG levels compared to their counterparts (P=0.010). Significant associated risk factors to hypoglycemia was NRG 1 levels, whereas low NRG 1 levels (<181 pg/mL) had higher risk to develop hypoglycemia (P=0.035; OR=4.86 (95% CI=1.11–21.16). Conclusion : Preterm infants with low NRG 1 levels have higher risk to develop hypoglycemia.