Volume : IV, Issue : II, February - 2015

Brain Injuries Induced by Experimental Renal Ischemia/Reperfusion in rat

Abdou, Rania H

Abstract :

Renal ischemia reperfusion (IR) occurs in a variety of clinical settings including shock, sepsis and vascular surgery. This study was conducted to investigate the renal IR induced ain injuries. rats were divided into two groups; IR group (bilateral occlusion of renal pedicles for 45 min followed by reperfusion) and sham group. Samples were taken 1 and 3 days after ischemia. serum was prepared for biochemical analysis and ain was divided into two parts for histological and immunehistochemical analysis. Our results revealed that serum concentrations of creatinine and BUN were significantly increased in IR group. MDA level was increased while, (SOD, CAT, GSH–Px, GST & GSH) levels were decreased in ain tissue of renal ischemic rats. Renal IR induced various degenerative changes in neuronal cells and apoptosis; shown by reduced expression of Bcl–2 and increased expressions of Bax and caspase–3. oxidative stress is thought to play the key role.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Abdou, Rania H Brain Injuries Induced by Experimental Renal Ischemia/Reperfusion in rat Global Journal For Research Analysis, Vol: 4, Issue: 2 February 2015

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