Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency in tertiary care centre in Kashmir valley between 1997 and 2017

Dr.Zhahid Hassan; Dr.Mahroosa Ramzan; Dr Mohsin

Volume : VIII, Issue : VI, June - 2019

Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency in tertiary care centre in Kashmir valley between 1997 and 2017

Dr. Zhahid Hassan, Dr. Mahroosa Ramzan, Dr Mohsin

Abstract :

Aims: To evaluate the incidence, gender, symptoms and age at diagnosis among patients with congenital adrenal hyperplasia (CAH) presenting to a tertiary care hospital. Methods: Data were collected retrospectively for all CAH diagnosed patients between 31.07.1997 and 31.06.2017 and were compared with the data of the previously conducted studies evaluating CAH patients discovered between 1964 and 1984. Results: During 20-year period, 30 classical CAH patients presented. There were 13 salt-wasting (SW) (8 females/ 5 males) and 17 simple virilizing (SV) patients (16 females/ 1 male). The lower incidence of SW boys compared to SW girls (8: 5) indicate that substantial proportion of SW boys die unrecognized. health care, diagnosis was established significantly earlier in SW and SV girls. During 1995–2006, none of the patients died following the diagnosis of CAH, and there was no erroneous sex assignment. Conclusion: Despite of improvement in health care, diagnosis of CAH in developing world is still delayed and some of the patients go unrecognized or die. Therefore, we think that the results of our study support the need for the introduction of newborn screening.