Clinical, Etiological and Biochemical Profile of a Hypokalemic Paralysis Patients - A Study from Burdwan Medical College, West Bengal

Annada Prasad Bhattacharya; Hilal Ahmad Ganaie; Javaid Ahmad Bhat; Sandip Paul

Volume : VIII, Issue : IV, April - 2019

Clinical, Etiological and Biochemical Profile of a Hypokalemic Paralysis Patients - A Study from Burdwan Medical College, West Bengal

Annada Prasad Bhattacharya, Hilal Ahmad Ganaie, Javaid Ahmad Bhat, Sandip Paul

Abstract :

Background:- . Hypokalemic Paralysis (HOP) is a channelopathy (typically involving voltage gated calcium or sodium) due to mutation of CACNA1S or SCN4A genes and accounts for large number of cases of acute flaccid paralysis. If properly diagnosed and treated, patients recover without much clinical sequlae. Objectives:- To study the varied clinical profile, etiological factors and biochemical abnormalities of subjects presenting with Hypokalemic paralysis. Result:- From 1st January 2013 to December 2014, 50 cases in the age group range 3 - 73 years presented with periodic paralysis. The study group comprised of both males and females in the ratio of M:F-2.8:1 The mean age of presentation of studied subjects was i36.28 + 15.90 (15-73). The highest cases are found in the age groups: 21 - 30 years(28%) & 41 -50 (28%) . Male and Female ratio 2.81:1. The clinical presentation was in the form of quadriparesis-42, paraparesis-5, hemiparesis -2 and isolated neck muscle weakness-1. Out of 30 idiopathic hypokalemic periodic paralysis cases ,2 cases were having positive family history. Among the 18 secondary HOP cases etiology varied from renal tubular acidosis-8, Gitelman Syndrome-2, Conn�s syndrome-2, 2 cases of thyrotoxic periodic palsy-2, two cases of alcohol induce hypokalaemia-2, one case is hypothyroid induced-1), another was iatrogenic-1. Conclusion:- We conclude that HOPP is an important cause of acute flaccid paralysis and early recognition and prompt management of this condition will give gratifying result and prevent further attacks in some cases