CLINICOPATHOLOGICAL ANALYSIS OF GLIOMAS - A SINGLE CENTER STUDY OF 263 CASES

Jayanandhini M; Sakunthala P; Sudha Venkatesh

Volume : IX, Issue : VI, June - 2020

CLINICOPATHOLOGICAL ANALYSIS OF GLIOMAS - A SINGLE CENTER STUDY OF 263 CASES

Jayanandhini M, Sakunthala P, Sudha Venkatesh

Abstract :

Introduction: CNS cancers affect both children and adult worldwide causing substantial morbidity and mortality. The most frequent primary malignant tumor of CNS is glioma. Gliomas are classified and graded histologically by WHO. Aims and Objectives: To analyse the clinicopathological profile of gliomas in Madras Medical College in Chennai, Tamil Nadu, India. Method: Data on age, sex, symptoms, radiological findings including CT and MRI, relevant investigations, per operative squash findings and gross findings, histologic subtype of all cases of gliomas diagnosed in Neuropathology department, Madras Medical College and Rajiv Gandhi Government General hospital, Chennai from January 2014 to December 2015 were obtained from clinicopathological documents. Histopathological slides were reviewed. Detailed clinical profile, radiological and pathological findings were analyzed. Results: In this study period, out of 836 cases, 263 cases were gliomas. Significant correlations were found between age and sex, age and various subtypes of glioma, sex and subtypes of gliomas, subtypes and grade of gliomas, sex and different grades of gliomas. Conclusion: In our study the peak incidence of gliomas observed was 41 -60 years. Gliomas show a male preponderance. Glioblastoma multiforme was the most common subtype and most of the Gliomas are WHO grade II followed by WHO grade IV tumors. This study presents diverse clinical and morphological spectrum of gliomas.