Comparison Of Sodium Bicarbonate And Nacl 0.9% Mouthwash In Preventing Oral Mucositis In Children With Hematologic Malignancy Undergoing Chemotherapy

Christina Hasibuan; Chairul Yoel; Josia Ginting; Karina Sugih Arto; Ayodhia Pitaloka Pasaribu; Bidasari Lubis

Volume : VIII, Issue : IV, April - 2019

Comparison Of Sodium Bicarbonate And Nacl 0.9% Mouthwash In Preventing Oral Mucositis In Children With Hematologic Malignancy Undergoing Chemotherapy

Christina Hasibuan, Chairul Yoel, Josia Ginting, Karina Sugih Arto, Ayodhia Pitaloka Pasaribu, Bidasari Lubis

Abstract :

Background. Oral health care is recommended for preventing oral mucositis or the progression of oral mucositis itself, one of its component is mouthwash. Sodium bicarbonate (SB) or NaCl 0.9% is still recommended, which one is more effective remains to be established. Methods. In April 2018 until December 2018, we conducted a prospective open-label randomized trial comparison of 4 weeks oral health care with NaCl 0.9% and SB mouthwash in pediatric patients with hematologic malignancy undergoing chemotherapy. Oral mucositis was assessed with WHO Oral Toxicity Scale and all patients were confirmed not having oral mucositis before the intervention. Data were analyzed using SPSS ver 20.0. We performed survival analysis with log rank test and omparison between groups were made by Chi square test, Fisher exact test, and Mann-Whitney U test where appropriate. Significance level of P <.05 and 95% CI. Result. Sixty-nine patients were included, 35 patients received SB and 34 patients received NaCl 0.9%. There were no sigificant difference in patients characteristics at baseline between two groups. From Kaplan Meier curve, there was no significant difference between the two groups for mean onset of oral mucositis in SB (11.32 days, median 10 days) and NaCl 0.9% group (11.93 days, median 11 days) (P=.763). Duration of oral mucositis was significantly different, in SB and NaCl 0,9% group were 4.86 days and 7.39 days respectively (P=.004). At the end of this study, incidence of oral mucositis was 47.8% in SB group and 48% in NaCl 0.9% group (P=.768). Conclusion. SB was not superior compared to NaCl 0.9% as mouthwash for preventing oral mucositis, but duration of oral mucositis was shorter in SB group.