CORRELATION OF DIAGNOSTIC UTILITY OF FNAC AND CORE BIOPSY IN BREAST CARCINOMAS WITH IHC ANALYSIS OF SELECTED CASES.

DR. SUMIT RAY; DR. DEBANGSHU GHOSH; DR. IRA MONDAL

Volume : VIII, Issue : VI, June - 2019

CORRELATION OF DIAGNOSTIC UTILITY OF FNAC AND CORE BIOPSY IN BREAST CARCINOMAS WITH IHC ANALYSIS OF SELECTED CASES.

Dr. Sumit Ray, Dr. Debangshu Ghosh, Dr. Ira Mondal

Abstract :

Breast cancer is a heterogeneous disease encompassing many morphological and molecular genetic entities like histological type, grade, hormone receptors and HER2 expression. They have been used to identify specific prognostic groups and predict response to the treatment. Fine Needle Aspiration Cytology (FNAC) is a relevant and important method to diagnose east cancer, but technical problems such as limited cellularity, excessive air drying and artifactual mechanical disaggregation can potentially limit the interpretation, as well as contribute to a false-negative or a false-positive diagnosis of malignancy, respectively. The major current limitation of FNAC is the separation of atypical ductal hyperplasia (ADH) from ductal carcinoma in situ (DCIS) and differentiating DCIS from invasive carcinoma, which affect the patient�s treatment. We carried out this study to compare between FNAC and semi-automated Core Needle Biopsy (CNB) to diagnose east carcinoma. We found that on comparative analysis between FNAC and CNB in the diagnosis of east carcinoma; sensitivity, negative predictive value, diagnostic accuracy were higher in case of CNB than those in case of FNAC. Immunohistochemistry (IHC) was done on tissues from CNB of all the diagnosed malignant cases and were categorised through ER,PR,HER2 and Ki67 staining in four group as Luminal A, Luminal B, HER2 Rich and Basal Like taking Ki67 cut up mark at 14%.We found that HER2 Positive primary tumour apparently was more associated with higher Grade and increased nodal involvement.