Depression, Antidepressants and Risk of Osteoporosis

Mina Cvjetkovic Bosnjak; Milana Okanovic; Aleksandra Nedic; Vesna Vasic; Branislav Sakic

Volume : VIII, Issue : I, January - 2019

Depression, Antidepressants and Risk of Osteoporosis

Mina Cvjetkovic Bosnjak, Milana Okanovic, Aleksandra Nedic, Vesna Vasic, Branislav Sakic

Abstract :

Objective: Depressive disorders and use of spetial kind of most prescribed antidepressant- Selective Serotonine Reuptake Inhibitors are often connected with low bone mineral density (BMD). As incidence of depression is very high (10-16%), anf first choice therapy for depression include SSRIs, aim of present study was to investigate if patients treated with this kind of antidepressants are at higher risk for osteoporisis compared with other antidepressives. If so spetial methods of prevention due to osteoporosis shoud be applied from the beginning of this therapy to prevent fractures and mortality of such patients. Materijal and Method 126 patients hospitalised at Psychisatric Clinic in Novi Sad, Serbia from 2014-2018. with diagnosis of depressive disorder, midlle intensity, (HAMA >20) , completed a comprehensive interwiev, had clinical measurements and BMD assessments at the spine,and total hip to find out if there sgns of disruption of mone metabolism. Patients were treated either with therapeutical dosis of SSRI )Selective Serotonin Reuptake Inhibitors)or SNRI (Selective Serononin and Noradrenalin Inhibitors)antidepressant . Result. Osteoporosis was found in higere percent in both group of patients, but there were no evidence that patients treated with SSRI were at higher risk of osteoporosis. Conclusion. In this investigation there were no difference of freqvence of osteopoenia and osteoporosis between patients treated with selective serotonine reuptake inhibiitors and patients treated with selectine noradrenaline reuptake inhibitors, but frekvence of osteopenia and osteopoorosis was higher in depressive patients compared to general population.