Volume : VIII, Issue : II, February - 2019

DESIGN AND EVALUATION OF GASTRO-RETENTIVE FLOATING TABLET OF SITAGLIPTIN

Abinash Routray, Amiya Kumar Prusty

Abstract :

The present study of Sitagliptin Floating tablets were to develop optimized gastric floating drug delivery system (GFDDS) by using the polymers HPMC K4M and Carbopol 940 to enhance the bioavailability and therapeutic efficacy of Sitagliptin. Various approaches have been followed to encourage gastric retention of an oral dosage form. Floating systems have low bulk density so that they can float on the gastric juice in the stomach. In the present work attempts have been made to prepare Sitagliptin Floating tablets by Direct compression method, 4 formulations (F1 to F4) floating tablets of Sitagliptin were prepared using variable concentrations of HPMCK4M and Carbopol940,buoyancy lag time and the total floating time was studied for all the formulations. FT-IR Studies shown that polymers are compatible with each other and there was no interaction found between polymer and drug.

Keywords :

Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

DESIGN AND EVALUATION OF GASTRO-RETENTIVE FLOATING TABLET OF SITAGLIPTIN, Abinash Routray, Amiya kumar Prusty GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-8 | Issue-2 | February-2019


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