EFFECT OF NITROGLYCERINE  ON  INTRINSIC VISCOSITY OF VARIOUS SALTS, SUGAR SOLUTIONS, CARBOHYDRTE, PROTEINS, AMINO ACIDS

Poonam Shinde; Sangeeta Parab; A.V.Chitre

Volume : V, Issue : VI, June - 2016

EFFECT OF NITROGLYCERINE ON INTRINSIC VISCOSITY OF VARIOUS SALTS, SUGAR SOLUTIONS, CARBOHYDRTE, PROTEINS, AMINO ACIDS

Poonam Shinde, Sangeeta Parab, A. V. Chitre

Abstract :

 Nitroglycerine is a vasodilatator used for the treatment of anginal attacks. Nitroglycerine decreases the smooth muscle tonus of blood vessels, mainly of the veins; through the local production of nitrous oxide (NO). Nitroglycerine is very liposoluble and is readily transported through memanes. Therefore, nitroglycerine is totally absorbed by the intestinal mucosa but undergoes a massive hepatic first pass effect, rendering its oral bioavailability negligible. Sublingual, intravenous or transdermal administration of nitroglycerin partially by passes this first pass effect, allowing plasma concentration to reach the therapeutic range. Nitric oxide (NO) is a highly reactive free radical which is emerging as an important mediator in much physiological and pathophysiological process. The discovery of nitric oxide as a signaling molecule began with studies on the mechanism by which blood vessels relax and constrict, processes known as vasodilatation and vasoconstriction. Viscosity, resistance of a fluid to a change in shape, or movement of neighbouring portions relative to one another. Viscosity is a measure of the internal friction of a liquid. As viscosity increases, the tendency to flow decreases. In the present study we proposed to observe the effect of nitroglycerine on viscosity of various salts, sugar solutions, carbohydrate, proteins and amino acid. This Study is found to provide interesting and significant data, which possibly may have correlation with significant intrinsic viscosity by addition of various amount nitroglycerine in these solutions.