Effect Of Non-Surgical Periodontal Therapy On Plasma Levels Of Fibrinogen in Patients with Chronic Generalized Periodontitis - A Pilot Study

Lt Col Raghavendra MH; Maj Devendra Srivastava; Col Manish Mukherjee; Col AK Shreehari; Col J Philip

Volume : VIII, Issue : II, February - 2019

Effect Of Non-Surgical Periodontal Therapy On Plasma Levels Of Fibrinogen in Patients with Chronic Generalized Periodontitis - A Pilot Study

Lt Col Raghavendra Mh, Maj Devendra Srivastava, Col Manish Mukherjee, Col Ak Shreehari, Col J Philip

Abstract :

Background: Emerging evidence from epidemiologic studies indicates that periodontal infection is associated with a moderate systemic inflammatory response . Fiinogen is a marker of inflammation, and their systemic levels have been associated with coronary heart disease. This pilot study was carried for the assessment of whether non-surgical periodontal treatment is associated with changes in plasma fiinogen levels in chronic generalized periodontitis. Methods: Five systemically healthy subjects with chronic generalized periodontitis participated in this one-month pilot study. Periodontal disease was measured through the clinical parameters including bleeding on probing (BOP), probing depth (PD) and clinical attachment loss. All subjects received non-surgical periodontal therapy that included scaling, root planning, oral hygiene instruction and chlorhexidine mouthwash. Systemic levels of inflammatory marker( Fiinogen) were measured prior at baseline and 1 month after non surgical periodontal therapy. The collected blood samples were sent to the laboratory for estimation of plasma fiinogen through STA analyser using commercially available STA fiinogen test kit. Results: The baseline of plasma fiinogen level in the selected sample was 408+/-150.7 mg/dl. After treatment, the plasma fiinogen levels reduced to 271+/-25.2 mg/dl. Together with the positive changes in parameters of periodontal disease, Non-surgical periodontal therapy resulted in a significant reduction (P <0.05) in the circulating levels of fiinogen after one month of treatment. Conclusions: In this study, Non-surgical periodontal treatment resulted in significant decrease in plasma fiinogen levels.