Volume : VIII, Issue : IX, September - 2019

Evaluation of E-Cadherin, MMP-2 in colorectal carcinoma

Hilal Erinanc, Emin Turk

Abstract :

Background : Colorectal cancer pogression is a multistep process, in which many genes and proteins are involved. Matrix metalloproteinase and loss of-E-Cadherin has been considered to be associated with cancer invasion and metastasis. In our study, we aim to evaluate the expressions of E-Cadherin and MMP-2 in colorectal carcinoma . Material and Methods: Expressions of E- Cadherin and MMP-2 in specimens from 48 colorectal adenocarcinomas ( 24 classic adenocarcinomas and 24 mucinous adenocarcinomas) were detected by immunohistochemistry. Results: MMP-2 expression was found 45,84% in classic adenocarcinoma while E-Cadherin was found 33,33% in mucinous carcinomas. Conclusion: Our findings demonstrate that E-cadherin and MMP-2 expression contributes to tumor development. It sems that MMP-2 expression was more associated with classic adenocarcinomas while E-Cadherin was related with mucinous adenocarcinomas .Further studies are need to find the correlations between E-cadherin ,MMP-2 and epithelial-mesenchymal transition.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

EVALUATION OF E-CADHERIN, MMP-2 IN COLORECTAL CARCINOMA, Hilal Erinanc, Emin Turk GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-8 | Issue-9 | September-2019

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