Volume : VIII, Issue : II, February - 2019
Evaluation of Homocysteine, C-reactive protein and lipid profile as markers of cardio vascular risk in women with Polycystic ovarian syndrome [PCOS]
Dr. P. R. Vanaja, Dr. Shruthi Mohanty
Abstract :
Objective: To determine Cardiovascular risk in patients with polycystic ovary syndrome (PCOS) and its relation to C-reactive protein (CRP) and homocysteine (Hcy) levels. Design: Cross sectional study. Setting: Kamineni Institute of medical sciences and hospital from 2012- 2014 Patient(s): Fifty women with PCOS and fty healthy women were included this study. Intervention(s): Cardiovascular risk was evaluated by measuring serum levels of CRP and Hcy and lipid prole. Results: There was an elevation of TC/HDL in 44% cases, with (P – 0.095) , elevation of LDL/HDL in 24%, cases with (P – 0.079) and lower levels of serum HDL in 58% cases, with (P – 0.001) . There was an elevation of serum Homocysteine levels in 58% cases, with (P – 0.001) . There was an elevation of serum CRP levels in 58% cases, with (P –0.001). In correlative studies Homocysteine correlates positively with VLDL(P-0.293) and CRP positively correlates with TC(0.037) and VLDL-C ( P-0.157). . Conclusion(s): In conclusion the ndings of the study show signicantly elevated levels of both lipid prole and homocysteine as cardiovascular risk markers in PCOS women. The various parameters like Serum TC, TG, LDL, VLDL, TC/HDL ratio, LDL/HDL ratio and TG/HDL ratio, homocysteine and CRP levels were elevated in the study group and also there was a reduction in the HDL levels in the study group. At the same time elevated inammatory risk markers CRP and homocysteine can cause endothelial dysfunction and thus increase the risk of early onset cardiovascular risk in these young women.
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DOI : https://www.doi.org/10.36106/gjra
Cite This Article:
EVALUATION OF HOMOCYSTEINE, C-REACTIVE PROTEIN AND LIPID PROFILE AS MARKERS OF CARDIO VASCULAR RISK IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME [PCOS] , Dr.P.R.VANAJA, Dr.SHRUTHI MOHANTY GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-8 | Issue-2 | February-2019
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EVALUATION OF HOMOCYSTEINE, C-REACTIVE PROTEIN AND LIPID PROFILE AS MARKERS OF CARDIO VASCULAR RISK IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME [PCOS] , Dr.P.R.VANAJA, Dr.SHRUTHI MOHANTY GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-8 | Issue-2 | February-2019