Evaluation of Homocysteine, C-reactive protein and lipid profile as markers of cardio vascular risk in women with Polycystic ovarian syndrome [PCOS]

Dr.P.R.VANAJA; Dr.SHRUTHI MOHANTY

Volume : VIII, Issue : II, February - 2019

Evaluation of Homocysteine, C-reactive protein and lipid profile as markers of cardio vascular risk in women with Polycystic ovarian syndrome [PCOS]

Dr. P. R. Vanaja, Dr. Shruthi Mohanty

Abstract :

Objective: To determine Cardiovascular risk in patients with polycystic ovary syndrome (PCOS) and its relation to C-reactive protein (CRP) and homocysteine (Hcy) levels. Design: Cross sectional study. Setting: Kamineni Institute of medical sciences and hospital from 2012- 2014 Patient(s): Fifty women with PCOS and 􀃶fty healthy women were included this study. Intervention(s): Cardiovascular risk was evaluated by measuring serum levels of CRP and Hcy and lipid pro􀃶le. Results: There was an elevation of TC/HDL in 44% cases, with (P – 0.095) , elevation of LDL/HDL in 24%, cases with (P – 0.079) and lower levels of serum HDL in 58% cases, with (P – 0.001) . There was an elevation of serum Homocysteine levels in 58% cases, with (P – 0.001) . There was an elevation of serum CRP levels in 58% cases, with (P –0.001). In correlative studies Homocysteine correlates positively with VLDL(P-0.293) and CRP positively correlates with TC(0.037) and VLDL-C ( P-0.157). . Conclusion(s): In conclusion the 􀃶ndings of the study show signi􀃶cantly elevated levels of both lipid pro􀃶le and homocysteine as cardiovascular risk markers in PCOS women. The various parameters like Serum TC, TG, LDL, VLDL, TC/HDL ratio, LDL/HDL ratio and TG/HDL ratio, homocysteine and CRP levels were elevated in the study group and also there was a reduction in the HDL levels in the study group. At the same time elevated in􀃸ammatory risk markers CRP and homocysteine can cause endothelial dysfunction and thus increase the risk of early onset cardiovascular risk in these young women.