Expression Analysis of IL-6 Levels In Cases of Endometriosis Compared to Controls and its Correlation with Different Stage Of Disease

Dr.Varsha H L; Prof Anuradha Khanna; Prof. Usha Singh

Volume : V, Issue : V, May - 2016

Expression Analysis of IL-6 Levels In Cases of Endometriosis Compared to Controls and its Correlation with Different Stage Of Disease

Dr. Varsha H L, Prof Anuradha Khanna, Prof. Usha Singh

Abstract :

Objective: To understand the role of inflammation in endometriosis by analyzing the expression of IL-6 in cases of endometriosis and its co-relation with different stage of disease. Materials and methods: 168 patients of chronic pelvic pain and or infertility were studied from july 2013-july 2015 in the Department of Obstetrics and Gynaecology, Immunopathology and Molecular and human genetics Dept, Institute of Medical Sciences, Banaras Hindu University, Varanasi . Patients were investigated for routine , infertility work up along with lapro hysteroscopy or laparotomy. Peripheral blood sample was taken to estimate for serum IL-6 level in immunology lab of immunopathology department, IMS, BHU. Results: Median IL-6 levels were very much elevated in all stages of endometriosis with compared to controls, severe type endometriosis had highest median IL-6 level. Conclusion: In our study we have found that IL-6, an inflammatory cytokine increased in ascending order with stage of the disease from minimum to severity.