FASTING OR POSTPRANDIAL LDL TO ACHIEVE LDL GOAL IN DIABETIC PATIENTS TAKING STATIN-A COMPARATIVE STUDY

Dr. Sri Charan K N; Dr. Rajesh Rajasekharan Pillai

Volume : VIII, Issue : IV, April - 2019

FASTING OR POSTPRANDIAL LDL TO ACHIEVE LDL GOAL IN DIABETIC PATIENTS TAKING STATIN-A COMPARATIVE STUDY

Dr. Sri Charan K N, Dr. Rajesh Rajasekharan Pillai

Abstract :

Background and objective Evidence based medicine shows that there is an increased risk of atherosclerotic heart disease with elevated levels of LDL cholesterol and the risks more than proportionate if two risk factors coexist. It is cumbersome to check fasting levels in diabetic patients as it is not feasible to keep them fasting for long periods .In view of this we decided to conduct a study to check if fasting or postprandial LDL to achieve LDL goal in diabetic patients taking statin . Material And Methods This study was conducted as a cross sectional study, wherein written informed consent will be taken prior to the investigation after detailed information given to the participants patient party regarding the study on patients of all ages admitted in A. J. Hospital with uncomplicated Diabetes Mellitus type 2 who met a predefined inclusion and exclusion criteria initiated after obtaining clearance from the institutions ethical committee. Total cholesterol assay was done using a modified method of Liebermann-Burchard HDL-cholesterol by precipitation method . TG was estimated using a kit employing enzymatic hydrolysis of TG with lipases LDL-C was calculated using the Friedwald�s formula. The data was collected in pre-prepared proforma and then transferred to a master chart for analysis.The collected data was analyzed using mean, mode for demographic data and frequency percentage for the analysis of the clinical data. Statistical Analysis was done using SPSS software version 23.0. A �p� value less than 0.05(p<0.05) is considered significant. Results and observations In the study conducted on 102 patients of all ages admitted in A. J. Hospital and we found that males were affected more than females in our study with diabetes .Among the lipid abnormalities HDL showed the least variation between different time intervals and TG the most .The abnormality of renal functions was directly related to the HBA1C Levels .LDL at fasting had a negative correlation with thyroid hormone levels Conclusions In our study we intended to study the significance lipid levels for follow up of patients on statin therapy we concluded the following • We recommend that statin use should be considered for any person with diabetes . • It is equally efficacious to check the post prandial or the fasting lipid levels for follow up of patients on statin therapy