FORMULATION AND EVALUATION OF FEBUXOSTAT MICROSPHERES FOR THE TREATMENT OF GOUT

Mahendra Kumar; Sagar Bansal; Raj K. Prasad; Atul K. Sahu

Volume : V, Issue : IV, April - 2016

FORMULATION AND EVALUATION OF FEBUXOSTAT MICROSPHERES FOR THE TREATMENT OF GOUT

Mahendra Kumar, Sagar Bansal, Raj K. Prasad, Atul K. Sahu

Abstract :

<p>&nbsp;The drug has to be delivered for a prolonged period of time and many medicines have to be taken simultaneously in case of chronic patients. . In order to overcome the above problems, various types of controlled release dosage forms and sustained release dosages forms are formulated and altered. In the present study an attempt has been made to formulate Febuxostat into a microspheres dosage form and prolong its gastric residence time, thus improving the oral bioavailability of the drug and reduces the side effects associated with the other medication of gout treatment. Gout is a painful and potentially disabling form of arthritis that has been around since ancient times. It would be faster and more economical to alter beneficially the properties of the existing drugs than developing new drug. Ethyl Cellulose was used as the wall material due to its safety, stability, hydrophobicity and perfect film forming nature among other polymers. Besides, Ethyl Cellulose has good release retardant property also it can be inferred that Ethyl cellulose can be a good choice to prepared microspheres of poorly water soluble drugs like Febuxostat.</p>