Glutamic pyruvic transaminase is positively correlated with insulin resistance in elderly

Jyh-Gang Leu; Yao-Jen Liang

Volume : VII, Issue : VIII, August - 2018

Glutamic pyruvic transaminase is positively correlated with insulin resistance in elderly

Jyh Gang Leu, Yao Jen Liang

Abstract :

Introduction

Taiwan is a hyperendemic area of hepatitis. Since liver is one of the major organs involved in glucose homeostasis and abnormal liver function might trigger the vicious cascade for glucose intolerance which eventually leads to type 2 diabetes (T2D). Custro et al. was the first one to note that hepatitis patients have a four times higher prevalence to have T2D than general population. Deterioration of insulin resistance (IR) was proposed to be responsible for this relationship.In the present study, our goal is to evaluate the relationship between liver function of glutamic pyruvic transaminase (GPT) and IR in the elderlies in both genders.

Methods

We randomly enrolled 19,067 men and 20,798 women who were aged over 60 years old from the private chain-clinics in 2013 and 2015. Subjects with different GPT were grouped. Scatter plots and slope were done in the current study.

Results

In both genders, BMI, WC, BP, FPG, TG, IR, and GPT, but lower HDL-C. All the participants were subdivided into four groups according to the quartiles of GPT results and subjects with a higher GPT were older, and had higher IR. The scatter plot of the correlation between IR and GPT showed positive correlation. We further demonstrate the slopes of the IR in men and women.

Conclusion

In the present study, we have showed that GPT is positively related to IR in elderly in both genders. Further longitudinal study to explore the cause-effect relationship between GPT and IR.