HISTOPATHOLOGICAL AND BIOCHEMICL STUDY OF ALKALI BURNS (KSHARA DAGDHA VRANA) IN ALBINO RATS

Dr. Sukrant Sharma; Dr. Ashanka Bhardwaj; Dr. Farookhahmed Kamagal; Dr. Sarabjeet Kour

Volume : VIII, Issue : IX, September - 2019

HISTOPATHOLOGICAL AND BIOCHEMICL STUDY OF ALKALI BURNS (KSHARA DAGDHA VRANA) IN ALBINO RATS

Dr. Sukrant Sharma, Dr. Ashanka Bhardwaj, Dr. Farookhahmed Kamagal, Dr. Sarabjeet Kour

Abstract :

Acharya Sushrutha mentioned alkali (kshara) as a substance which does deidement (ksharana) and cutting properties (kshanana) and mentioned its properties like excision (chedana), incision (bhedana), scrapping (lekhana), purification (shodhana), healing (ropana) , cauterization(dahana)etc. How a strong alkali, after injuring tissue, can itself induce healing needs investigation. With this objective, this experimental study on Albino rats was planned to observe and measure alkali induced tissue injury and its subsequent healing. Findings were compared with healing pattern of topical chemical tissue injury and healing using 2N-NaOH (2normal saline sodium hydroxide). The parameters for assessing tissue injury and subsequent healing were total hematology, C-reactive protein, total protein, tissue hydroxyproline and histopathological study. The study revealed that the rate and extent of healing post-alkali (trial group) injury is much higher compared to chemical injury induced by 2N-NaOH (standard). Lesions treated by applying alkali leave wounds and these wounds need not be treated by other healing medicine. The alkali itself has property which leads to healing of its own wounds.