Volume : V, Issue : VII, July - 2016

Hurthle Cells in Thyroid Cytology

V. Eswari, S. Archana, C. Vignesh, V. Bhanumathy

Abstract :

 Aim: Fine needle aspiration cytology of the thyroid gland is firmly established as a first line diagnostic test for the evaluation of goiter and the single most effective test for the preoperative diagnosis of a solitary thyroid nodule. Hurthle cells are of uncertain significance in thyroid disease and the aim of this study is to clarify the meaning and predictivity of Hurthle cells in Fine needle aspiration cytology for thyroid nodular disease. Materials and methods: A total of 210 thyroid Fine Needle Aspiration Cytology smears were studied ,out of which 103 smears showed Hurthle cells with varying morphological features. Smears were stained with Haematoxylin and Eosin stain and May Grunwald Giemsa stain. The cytological smears were studied on the basis of cellularity, amount of colloid, macrophages, lymphocytes, plasma cells, percentage of Hurthle cells compared with all follicular cells, percentage of single Hurthle cells ,cellular arrangement, cohesion, nuclear enlargement, nuclear pleomorphism, nucleoli and binucleation or multi nucleation. Results : Hurthle cells in the neoplasm was compared with non neoplastic Hurthle cell lesions. Statistical analysis was performed with Chi-Square test and statistically significant differences were noted. A P value < 0.05 was considered significant. Conclusion: We conclude that Cytological features of Hurthle cells varied in different lesions of the thyroid, which enables us to differentiate between non-neoplastic and neoplastic lesions and could also guide the clinicians regarding further therapeutic management.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

V. Eswari, S. Archana, C. Vignesh, V. Bhanumathy Hurthle Cells in Thyroid Cytology Global Journal For Research Analysis, Volume : 5 | Issue : 7|July 2016

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