Volume : IV, Issue : VII, July - 2015

Implications of free radicals in different stages of breast cancer

Neha Sharma, D. S. Rathore, Meenu Rai

Abstract :

Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals include reactive oxygen and nitrogen species, which are key players in the initiation and progression of tumor cells and enhance their metastatic potential. In fact, they are now considered a hallmark of cancer. However, both reactive species may contribute to improve the outcomes of radiotherapy in cancer patients. Besides, high levels of reactive oxygen species may be indicators of genotoxic damage in non-irradiated normal tissues. The purpose of this article is to review recent research on free radicals and carcinogenesis in order to understand the pathways that contribute to tumor malignancy. This work involves the free radicals in relevant cellular events, including their effects on DNA damage. This knowledge is crucial for evaluating the relevance of free radicals as therapeutic targets in cancer.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Neha Sharma, D.S. Rathore, Meenu Rai Implications of Free Radicals in Different Stages of Breast Cancer Global Journal For Research Analysis, Vol: 4, Issue: 7 July 2015

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