Increasing endometrial thickness in management of infertility by using Sildenafil: Interventional study in western India.

Dr Anubhooti Trivedi; Dr Kiran Borkar

Volume : VI, Issue : XI, November - 2017

Increasing endometrial thickness in management of infertility by using Sildenafil: Interventional study in western India.

Dr Anubhooti Trivedi, Dr Kiran Borkar

Abstract :

Introduction-An important factor in infertility is thin endometrial thickness (ET). Pregnancy rate was higher in endometrial thickness 6-10mm. Also an adequate ET is an important necessity for favorable IVF outcome. Sildenafil a 5- phosphodiesterase type 5 (PDE5) inhibitor increases endometrial thickness when administered intravaginally.

Methods- An experimental interventional design was conducted at Dept of OBG-GYN at JNMC, DMIMS, Wardha from August 2016-June 2017. Females seeking treatment for Assisted Reproductive technique (ART) with less endometrial thickness were included in study.

They were asked to self-administer per vaginal sildenafil & the response was assessed using Trans Vaginal Sonography (TVS). The data was collected using pre-formed pre-tested questionairre, complied,analyzed & using MS-Excel 2007.Data was interpreted using proportions & appropriate tests of significance.

Result- In total 107 participants were taken but 03 subjects were lost in follow up.There is no statistically significant association of age with type of infertility.(p>0.05) Prior to use of Sildenafil, in total 39.42% females had endometrial thickness of > 4.1mm, 33.65% females had endometrial thickness of > 5.1 mm. Following use of Intravaginal Sildenafil, a statistically significant increase in ET by 1.5mm was noted. During the study no significant adverse effect was reported by any participants.

Conclusion- Hence use of intravaginal sildenafil causes statistically significant increase in Endometrial thickness.