Volume : VIII, Issue : I, January - 2019

Intraperitoneal administration of chemotherapy in advanced stages ovarian cancer

Emmanuel N Kontomanolis, Georgiou Nikolaos, Kalagasidou Sofia, Papamanolis Valentinos, Zacharias Fasoulakis

Abstract :

Introduction: Ovarian cancer represents one of the major concerns in the everyday clinical practice as it known to be the most lethal gynecological malignancy with most of the patients being diagnosed at a late stage. The aim of this paper is to provide an up to date and discuss the recent available literature considering the use of intraperitoneal chemotherapy in advanced stages of ovarian cancer. Methods: The latest available literature in PubMed regarding the use of intraperitoneal administration of chemotherapy in advanced stages of ovarian cancer was searched, from 2017-2018 related articles. Results: Results of chemotherapy depend on the administration way. Studies support that intraperitoneal chemotherapy for advanced stages of ovarian cancer offers significant advantages, better prognosis while increases overall survival. Of great importance seems to be the intraoperative hyperthermic intraperitoneal chemotherapy that reaches much better results compared to current therapies. Conclusions: Current routine therapies do not significantly improve the prognosis of patients, therefore novel therapeutic options are being explored to enhance the current treatment efficiency against ovarian cancer. Conventional intravenous administration of chemotherapy is proven to be one of the most effective therapeutic options, however, intraoperative hyperthermic intraperitoneal chemotherapy combined to cytoreductive surgery seems to achieve prosmising results in overall survival, however, further studies are needed to reach safe conclusions.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

INTRAPERITONEAL ADMINISTRATION OF CHEMOTHERAPY IN ADVANCED STAGES OVARIAN CANCER, Emmanuel N Kontomanolis, Georgiou Nikolaos, Kalagasidou Sofia, Papamanolis Valentinos, Zacharias Fasoulakis GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-8 | Issue-1 | January-2019


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