Volume : IV, Issue : IV, April - 2015
Leptin Receptor Expression in Parathyroid Cancer
Zorka Inic, Momcilo Inic, Snezana Jancic, Ivan Paunovic, Milan Zegarac, Ivana Inic
Abstract :
Background:
Epidemiology studies have shown that there is a strong, positive correlation between obesity and the incidence of
several types of carcinoma. One of the most important mediators correlating between obesity and an increased risk of cancer is leptin, which is
an adipokine whose major functions are regulating appetite and energy homeostasis. However, no previous studies have yet to examine leptin
or its receptor expression in parathyroid cancer (PC).
PC is a rare malignancy which accounts about 1% of the cases of primary hyperparathyroidism.
Methods:
In this study, the expression of leptin receptors (OBRs) was examined in 10 parathyroid cancer samples using immunohistochemistry, for which
their associations with clinicopathological parameters were also evaluated. Ten patients (six men, four women) underwent operations for
parathyroid carcinoma and primary hyperparathyroidism (HPTH) at the Clinical Centre of Serbia. All patients had hypercalcemia (a mean of 3.55
mmol/l) and elevated parathyroid hormone (a mean of 1824 pg/ml).
Results:
The expression of leptin is associated with OBRs, which were observed in the tumor cell memane and/or cytoplasm of these patients, at a
positive rate of 40 %. The Mann–Whitney Test confirmed a statistically significant difference (p=0.033) in the glands weight which was not
possible to find in regard to parathyroid hormone, calcium, glands size, multifocality or age, due to the size of the sample, although they were
increased in this group.
Conclusion:
The results of the researches have found that the expression levels of leptin and OBRs are mutully associated and have a role in the development
of a large variety of malignancies promoting angiogenic factors that increase cancer cell survival, proliferation, and migration. The results
signify the expression of leptin and/or OBRs in parathyroid cancer to be associated with parathyroid weight and may be a potential target in
parathyroid cancer.
This is still the first report. Further research is necessary in order to determine the potential prognostic and thearapeutic implication of the leptin/
OBRs system and whether a correlation exists with other clinicopathological features.
Keywords :
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DOI : https://www.doi.org/10.36106/gjra
Cite This Article:
Zorka Inic, Momcilo Inic, Snezana Jancic, Ivan Paunovic, Milan Zegarac, Ivana Inic Leptin Receptor Expression in Parathyroid Cancer Global Journal For Research Analysis, Vol: 4, Issue: 4 April 2015
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References :
Zorka Inic, Momcilo Inic, Snezana Jancic, Ivan Paunovic, Milan Zegarac, Ivana Inic Leptin Receptor Expression in Parathyroid Cancer Global Journal For Research Analysis, Vol: 4, Issue: 4 April 2015