Volume : VI, Issue : II, February - 2017

Liver diseases in the school going child (4-15 years)

Heena Maulek Desai, Meenakshi Balasubramanian

Abstract :

 Background: The aim of our study was to study the clinical profile, evaluate the findings in various liver and hepatobiliary diseases on liver biopsy in pediatric patients (age group 4-15years). Also, to correlate the histopathological findings with the possible clinical presentation in chronic liver disease, to assess the prognosis, outcome and effects of treatment of chronic liver disease proven by biopsy.

Materials and methods: In this 5 year study, all liver biopsies and selective autopsy cases of children between 4-15 years of age were included. Wilson’s work up included tests like S.ceruloplasmin, 24 hour urinary copper, post penicillamine 24 hour urinary copper, Kayser Fleischer ring, dry weight of copper, MRI Brain and family screening. The liver biopsies were stained with hematoxylin and eosin (H &E) stain. Also reticulin stain was done in all cases.

Results: In 57 cases, majority were in the 4-7 year age group (49.1%). The most common presenting feature was jaundice (64.9%). The most common histopathological diagnosis included acute and chronic hepatitis, cirrhosis and liver with non specific features. Portal tract inflammation and abnormal liver architecture were found in almost all diagnosed cases of Wilson’s disease. The most commonly correlated cases (34 cases) included 5 cases of chronic active hepatitis, 4 cases each of Wilson’s disease and cirrhosis of liver, 3 cases each of Extra-hepatic portal vein obstruction, acute hepatitis and  massive liver cell necrosis.

Conclusion: Liver biopsy can help in giving a definitive diagnosis in most of the cases and can be valuable in cases with clinical overlap. 

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Heena Maulek Desai, Meenakshi Balasubramanian, Liver diseases in the school going child (4-15 years), GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-6, Issue-2, February‾2017

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