Volume : V, Issue : III, March - 2016

MUTAGENIC POTENTIAL OF BILE SPECIMEN FROM CARCINOMA GALL BLADDER

Dr. Harishankar Singh, Dr. Rajneesh Gour

Abstract :

 BACKGROUND: Gall bladder cancer is the most common type of malignancies of the gastrointestinal tract (80-95%). Our aim was to study the mutagenic potential of bile specimens in gall bladder cancer and also to study the epigenetic alteration in gall bladder cancer and gall stone disease. MATERIAL AND METHODS: 95 bile samples (35 from ca gall bladder and 60 from cholelithiasis/ cholestasis) were collected and studied for genetic mutations in tumor suppressor genes through tester strains of Salmonella typhi. RESULTS : Two strains TA1535 and TA1538 were found with rfa mutations and third strain TA97a as found with uvrB mutations. All the genes p15, p16 and CDH1, that we had screened were found to be methylated in the promoter region in all the 35 gall bladder cancer patients (p<0.001). while the rest 60 cholelithiasis cases didn’t show methylation. CONCLUSION : The epigenetic alterations in carcinoma of gall bladder patients may probably be induced by the degrading potential of the bile salts.

Keywords :

Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

DR.HARISHANKAR SINGH, DR.RAJNEESH GOUR MUTAGENIC POTENTIAL OF BILE SPECIMEN FROM CARCINOMA GALL BLADDER Global Journal For Research Analysis, Vol: 5, Issue : 3 March 2016


Number of Downloads : 318


References :