Volume : IV, Issue : VII, July - 2015

Neurohistological Effects of Lead on Hippocampus of Adult Albimo Rat

Dr S M Dawar Husain

Abstract :

LEAD is toxic to every organ of body, including central nervous system. This study is aimed to observe the histopathological changes in the hippocampus of rat induced by oral administration of lead compound in adult albino rats. Total number of 20 adult albino rats of either sex were included in the present study, consisting of equal numbers in both control and experimental groups. Experimental group received 4% aquous lead acetate orally for 15 days., then animals of both groups were anaesthetized with ether and perfused with 10% formalin. Hippocampus was dissected. 10µ thick sections were obtained by usual histological procedure and were stained with Nissl stain. On light microscopic observation, hippocampus from experimental group revealed shrunken neurons, shrinkage of the layers associated with area of vacuolation. It was concluded that lead has toxic effects on the central nervous system including hippocampus which may explain the clinical manifestation of lead neurotoxicity

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Dr S M Dawar Husain Neurohistological Effects of Lead on Hippocampus of Adult Albimo Rat Global Journal For Research Analysis, Vol: 4, Issue: 7 July 2015

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