Prognostic classification of Breast carcinoma on molecular basis using ER, PR, Her-2/neu and ki67: A study conducted on 56 patients in RIMS, Ranchi, Jharkhand, India

Alok Kumar; Ratna Chaudhary; Arvind Kumar; Abhishek Verma

Volume : VI, Issue : XII, December - 2017

Prognostic classification of Breast carcinoma on molecular basis using ER, PR, Her-2/neu and ki67: A study conducted on 56 patients in RIMS, Ranchi, Jharkhand, India

Alok Kumar, Ratna Chaudhary, Arvind Kumar, Abhishek Verma

Abstract :

Objective:

To classify the cases of east carcinoma coming to RIMS, Ranchi into Luminal A, B, Her-2/neu and basal like using IHC Markers- ER, PR, Her-2/neu and ki67

Materials and methods:

In our study on 56 patients with east carcinoma, were taken into account and the expression of Hormonal, markers ER, PR, Her-2 and ki67 were determined by immune-histo-chemistry and classification into Luminal A, B, Her-2 and Basal like were done subsequently.

Results:

During the study period a total of 56 cases of Breast carcinoma were subjected to immune-histo-chemistry. The maximum number of patients was in the age group of 51-60 years of age. The study comprised mainly of females with a male to female ratio of 1:28. Histologically, 51 cases (91.07%) were invasive ductal carcinoma NOS. As per Bloom Richardson grading, 23 patients (41.07%) were of Grade I, 19 patients (33.92%) of Grade II and 14 patients (25%) of Grade III. Out of 14 cases of Bloom Richardson Grade III, 9 had high ki67 index (64.28%). A low Ki67 index was present in 40 cases of Grades I and II (95.23%)

P Value using Fisher�s Exact Test = 0.0001 (statistically high significant correlation).

Depending on IHC markers ER, PR, Her-2/neu, and Ki67, molecular subtyping into Luminal A patients were 43 (76.78%), Luminal B were 10 (17.85%), Her-2/neu enriched-1 (1.78%) and Basal like-2 (3.57%).