PROGNOSTIC IMPLICATIONS OF MICROALBUMINURIA IN NON-DIABETIC, NON-HYPERTENSIVE PATIENTS WITH ACUTE CORONARY SYNDROME

SUPRABHAT GIRI; NAMITA MOHANTY

Volume : VI, Issue : IV, April - 2017

PROGNOSTIC IMPLICATIONS OF MICROALBUMINURIA IN NON-DIABETIC, NON-HYPERTENSIVE PATIENTS WITH ACUTE CORONARY SYNDROME

Suprabhat Giri, Namita Mohanty

Abstract :

Background: Microalbminuria is a major risk factor predisposing to cardiovascular morbidity and mortality but very limited evidence are there to suggest it�s use as a prognostic tool to determine in-hospital morbidity and mortality. The aim of this study was to examine the presence of microalbuminuria as a predictor of major adverse cardiac events in non-diabetic,non-hypertensive patients with acute coronary syndrome.

Methods: Fifty five non-diabetic, non-hypertensive patients with acute coronary sydrome were studied prospectively. A comparison of in-hospital mortality and major non-fatal in-hospital events between microalbuminuric and normoalbuminuric patients was done.

Results: In the study group 52.7% patients developed an in-hospital event (fatal or non-fatal). Microalbuminuric had a higher mortality rate in comparison with normoalbuminuric but it was not significant (p=0.146). The incidence of arrhythmias (p=0.029) and cardiogenic shock (p=0.042) were significantly higher in patients with microalbuminuria. The combined end-point of the total number of fatal and non-fatal events was significantly higher in patients with microalbuminuria (p=0.002). In multiple logistic regression analysis, microalbuminuria (p=0.030) was independently related to the occurrence of major in-hospital events.

Conclusions: Microalbuminuria is a significant predictor of in-hospital morbidity and mortality in non-diabetic patients with acute myocardial infarction.