Study of Biomarkers for Assessing Risk Factors for Coronary Artery Disease in North Indians

Professor(Dr).Vishvanayak; Dr. B. Kumar

Volume : V, Issue : V, May - 2016

Study of Biomarkers for Assessing Risk Factors for Coronary Artery Disease in North Indians

Professor Dr . Vishvanayak, Dr. B. Kumar

Abstract :

Our Study is a case control study and was carried out to study the risk factors for coronary artery disease in North Indians. The diagnosis of coronary artery disease was based on correlation of clinical, biochemical, electrocardiography, echocardiography, treadmill testing and coronary angiography findings. The study comprised 100 cases of coronary artery disease (acute coronary syndrome and chronic coronary artery disease) and 100 controls in a tertiary care hospital of North India. The subjects were evaluated for total plasma homocysteine, insulin, C-reactive protein (CRP), lipoprotein fiinogen and anti-chlamydial antibodies. Male to female ratio was 10:1 in study group with similar predominance of males in controls. Mean age of the cases was 46 years (range 25-59 years) and that of controls was 44 years (range 23-56 years). 64% cases had acute coronary syndrome and 34% had chronic coronary artery disease. In the coronary artery disease population, 76% cases had hyperhomocyteinemia, 9% hyperinsulinaemia, 11% abnormal CRP values, 23% abnormal lipoprotein A levels, 40% IgG anti-chlamydial anti-bodies and only 11% had Ig M anti-chlamydial antibodies. In the control population, 72% had hyperhomocystinaemia and 6% hyperinsulinaemia while 23 % and 9% controls had IgG and IgM anti chlamydial antibodies respectively. In control group 19% cases had abnormal lipoprotein A levels and only 2% had abnormal C reactive protein values. Significant correlation of CAD was seen with CRP values and Ig G anti-chlamydial antibodies. Both the study group and controls had higher homocysteine levels. High C reactive protein levels and Ig G anti-chlamydial antibodies are associated with coronary artery disease. Insulin, lipoprotein A, fiinogen, lgM anti-chlamydial antibodies and higher levels of total plasma homocysteine have no significant association with coronary artery disease.