STUDY OF CORRELATION OF HUMAN PAPILLOMA VIRUS WITH ORAL CAVITY & OROPHARYNGEAL SQUAMOUS CELL CARCINOMA.

Satpinder Kaur; Rajashri Mane; Vishal Salhotra; Anjana Mohite

Volume : VIII, Issue : VII, July - 2019

STUDY OF CORRELATION OF HUMAN PAPILLOMA VIRUS WITH ORAL CAVITY & OROPHARYNGEAL SQUAMOUS CELL CARCINOMA.

Satpinder Kaur, Rajashri Mane, Vishal Salhotra, Anjana Mohite

Abstract :

A prospective cohort clinical study was carried out at Dr.D.Y.Patil Hospital & Research Institute, Kohlapur from May 2014-May 2016. An attempt was made to correlate the Human Papilloma Virus in Oral Cavity and Oropharyngeal Squamous Cell Carcinoma. Real time Polymerase Chain Reaction technique using consensus HPV primers was used to detect HPV type 16 & HPV type18 in punch biopsy specimens from 70 patients of oral cavity & oropharyngeal squamous cell carcinoma. Data was collected from all patients by giving questionnaire and statistically analysed by applying chi-square test. 83.33% of HPV were detected in Oral cavity Squamous cell carcinoma & 16.66% of HPV were detected in Oropharyngeal Squamous cell carcinoma. Among HPV positive , majority 66.66% were HPV type 16 , 33.33% were HPV type16 & HPV type18 combined. HPV positive cases showed better prognosis & overall survival as compared to HPV negative cases. Thus we conclude that HPV positive cancers differ significantly from HPV negative cancers with regards to patient�s age, gender, addiction, site of tumour and stage.