STUDY OF CYTOGENETIC PROFILE IN PATIENTS OF ACUTE LEUKEMIA AND ITS CORRELATION WITH TREATMENT OUTCOMES

Dr Sanjeevan Sharma; Dr Vivek Thakur; Dr Gaurav Mahajan; Dr K Satyanand

Volume : VII, Issue : XII, December - 2018

STUDY OF CYTOGENETIC PROFILE IN PATIENTS OF ACUTE LEUKEMIA AND ITS CORRELATION WITH TREATMENT OUTCOMES

Dr Sanjeevan Sharma, Dr Vivek Thakur, Dr Gaurav Mahajan, Dr K Satyanand

Abstract :

Introduction: Acute leukemia is a malignant disease of hematopoietic precursors which is universally fatal if untreated. All cases of acute leukemia arise due to an underlying cytogenetic abnormality, and this mostly dictates its biological behaviour, response to chemotherapeutic agents and thus the prognosis.

Methods: 101 patients of acute leukemia diagnosed and treated in a single tertiary care centre between 2014 to 2017 were analysed for their cytogenetic profile, and its effect on their ability to achieve a remission post chemotherapy.

Results: 56% of patients had some cytogenetic abnormality, and 22% out of these patients had poor risk cytogenetic profile. 24% patients died whereas 74% achieved and remained in remission at the end of 6 months follow up period. The mortality or the remission status at 6 months was not statistically different between poor and other cytogenetic risk groups.

Conclusion: Cytogenetic profile is an important prognostic marker in acute leukemia, but in our study it did not corelate with ability to achieve remission state post chemotherapy at a 6 month period.