Study of Post Prandial Lipid Abnormality in Type 2 Diabetes Mellitus and its Relation with Cardiovascular Complications

Dr Pranay Dhurvey; Dr Robin Lakra

Volume : IX, Issue : I, January - 2020

Study of Post Prandial Lipid Abnormality in Type 2 Diabetes Mellitus and its Relation with Cardiovascular Complications

Dr Pranay Dhurvey, Dr Robin Lakra

Abstract :

Background: Various studies have shown that postprandial dyslipidaemia is more important in the pathogenesis of the vascular changes and atherosclerosis and that it increases the risk of the cardiovascular events. Aims and Objectives: To study the post prandial lipid abnormalities in T2DM and compare with cardio vascular complication. Materials and Methods: Hundred subjects were studied after dividing them in to Cases (n=50) and Control (n=50) at department of Medicine Gandhi Medical College, & associated Hospitals (Hamidia Hospital) Bhopal from Aug 2018 to July 2019. Fasting and Postprandial Blood Sugar (FBS) (PPBS), Glycosylated Haemoglobin (HbA1c), Lipid Profile (Fasting and post prandial), ECG, and TMT was performed for all the patients. Results: Out of 50 patients, 70% had abnormal TG, 56% had abnormal TC, 36% had abnormal HDL and 52% had abnormal LDL. On comp� post prandial lipid abnormality between diabetes and non-diabetes patients, it was found that there was significant difference in terms of post prandial lipid abnormality as revealed by the significant p value of <0.001. Out of 35 patients with abnormal TG, 85.7% had abnormal ECG and out of 28 patients with abnormal TC, 71.4% had abnormal ECG. Similarly out of 18 abnormal HDL patients, 83.3% had abnormal ECG and out of 26 patients with abnormal LDL, 92.3% had abnormal ECG finding. Majority of patients with normal post prandial lipid profile had normal ECG findings. On comp� the lipid profile with TMT findings it was found that majority of patients with abnormal post prandial lipid profile had positive TMT. Conclusion: Post prandial lipid profile abnormality is common among the T2DM patients which significantly correlates with positive TMT result and also significant ST-T changes in ECG.