STUDY ON URIC ACID LEVELS IN VARIOUS STAGES OF CHRONIC KIDNEY DISEASE

Senthilkumar PK; Saradha M; Heber Anandan; SriMeeenakshidevi

Volume : V, Issue : IX, September - 2016

STUDY ON URIC ACID LEVELS IN VARIOUS STAGES OF CHRONIC KIDNEY DISEASE

Senthilkumar Pk, Saradha M, Heber Anandan, Srimeeenakshidevi

Abstract :

Introduction: Chronic Kidney Disease (CKD) is defined as presence of markers of kidney damage for 3 months as defined by structural or functional abnormalities of the kidney with or without decreased GFR. Uric acid levels increases with progression of kidney dysfunction since uric acid is primarily excreted by the kidney. Uric acid is also considered to be a risk factor in the progression of atherosclerosis and coronary heart disease which is the most common cause of death in CKD population. Aim: To study the level of uric acid level in various stages of chronic kidney diseases and to study the relationship of hyperuricemia with progression of stages of CKD and hypertension. Methods: Prospective study was conducted in patients with chronic kidney disease. Serum samples were collected and analyzed for the uric acid and creatinine level. Patients were categorized into various stages of CKD on the basis of GFR. GFR is calculated using Cockcroft-Gault formula with the available data. Results: Presence of uric acid level above 7.0 mg/dL in males and above 5.6 mg/dL in females was taken as criteria for detecting hyperuricemia. Incidence of hyperuricemia in CKD patients (including all stages) was 71.5%. Conclusion: The uric acid level increased significantly with progression of stages of CKD. Stage V CKD has significant correlation with hyperuricemia. Hyperuricemia has also been strongly associated with hypertension.