Warm Autoantibody With Underlying Anti-E Alloantibody In A Child: A Diagnostic Challenge And Its Implications

Dr Geetika Sharma; Dr Deeksha Singh; Dr Preeti Rai; Dr Jyoti Garg

Volume : VIII, Issue : I, January - 2019

Warm Autoantibody With Underlying Anti-E Alloantibody In A Child: A Diagnostic Challenge And Its Implications

Dr Geetika Sharma, Dr Deeksha Singh, Dr Preeti Rai, Dr Jyoti Garg

Abstract :

Every immuno-hematologist is faced with two challenges: 1) Reduce the risk of alloimmunisation in patients and 2) Identification of alloantibody in immunized individuals; so that corresponding antigen-negative blood unit is transfused in future to avoid hemolytic transfusion reaction. However, sometimes the alloantibody may be masked by coexistent autoantibody leading to difficulty in alloantibody identification and cross-match. We hereby present a case of warm autoantibody with alloantibody presenting as cross-match incompatibility with special emphasis on diagnostic work-up