Evaluating Musculoskeletal Complications Among Individuals With Diabetes Mellitus

Dr. Simran Maheshwari; Dr. Subhan Quraishi; Dr. Babita Ghodke

Volume : II, Issue : V, May - 2013

Evaluating Musculoskeletal Complications Among Individuals With Diabetes Mellitus

Dr. Simran Maheshwari, Dr. Subhan Quraishi, Dr. Babita Ghodke

Abstract :

Staphylococcins are bacteriocins produced by Staphylococci, which are gram positive bacteria with medical and veterinary importance. Most bacteriocins produced by Staphylococci are either lantibiotics (e.g. Pep 5, epidermin, epilancin k7, epicidin 280, Staphylococcin c55/Bac R1 and nukacin ISK–1) or class II bacteriocins (e.g. Aureocins A70 and 53). Only one Staphylococcin belonging to class III, lysostaphin, has been described so far. Production of Staphylococcins is a self protection mechanism that helps Staphylococci to survive in their natural habitats. However, since these substances generally have a oad spectrum of activity, inhibiting several human and animal pathogens it can be used as an antimicrobial agent . X ray crystallography can determine the size of atoms , the lengths and types of chemical bonds , and the atomic scale difference among various materials. The aim of this work was to study the effectiveness of staphylococcin isolated from MRSA against the MRSA strain.Methicillin resistant Staphylococcus aureus strain, which is a bacteriocin producer was isolated, purified by ammonium sulphate precipitation test and dialysis.Molecular weight was determined by using Tricine SDS–PAGE and XRD analysis of staphylococcin was done.