Introduction: Intensive care units create opportunity for recovery in patients who otherwise may not have died, However, they are at times associated with problem of nosocomial infections. Inspite of availability of newer antimicrobials the treatment of VAP has proved to be difficult. The clinical presentation and organisms causing the VAP are different in different set ups. Aims and Objectives: To study the incidence ,clinical profile and organisms with antibiogram of VAP.patients admitted in ICU settings. Materials and Methods: A total of 60 Patients who were admitted in medical intensive care unit on mechanical ventilator who developed pneumonia and fulfilling inclusion criteria were studied. These patients were investigated clinically, radiologically and bacteriologically to determine presence of pneumonia, isolate causative microorganism and presence of co morbid conditions like DM, COPD, CRF etc. Results and Conclusion: Crepitation (83%) was the commonest sign in patients and early onset VAP. Fever and tachycardia were the commonest sign in patients with late onset (61%) VAP. Overall all the three signs were the commonest in all VAP patients (48% each). Pseudomonas and staphylococcus aureus (21%) each were the commonest bacteria isolated in early onset VAP. Pseudomonas (52%) was the commonest bacteria isolated in patients with late onset VAP. Overall pseudomonas (37%) was the commonest organism isolated in VAP. Hence there is every need for early diagnosis and management of these patients to decrease morbidity and mortality.